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A 1997 polysomnography RCT by Copinschi and colleagues, published in Neuroendocrinology, randomized healthy young and older adults to 7-day MK-677 or placebo and found an approximately 50% increase in stage IV slow-wave sleep in younger subjects and approximately 50% increases in REM sleep duration in older subjects, with decreased abnormal sleep episodes in both groups

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W niektórych krajach trwają również badania nad jego potencjalnym zastosowaniem w leczeniu chorób neurodegeneracyjnych oraz stanów zapalnych o podłożu autoimmunologicznym